Activation of the "Splenocardiac Axis" by Electronic and Tobacco Cigarettes in Otherwise Healthy Young Adults

Article English OPEN
Boas, Zachary; Gupta, Pawan; Moheimani, Roya S; Bhetraratana, May; Yin, Fen; Peters, Kacey M; Gornbein, Jeffrey; Araujo, Jesus A; Czernin, Johannes; Middlekauff, Holly R;
(2017)
  • Publisher: eScholarship, University of California
  • Journal: volume 5, issue 17 eissn: 2051-817X
  • Publisher copyright policies & self-archiving
  • Identifiers: doi: 10.14814/phy2.13393, pmc: PMC5599858
  • Subject: Skeletal | electronic cigarettes | Medical Physiology | Tobacco Smoke and Health | hematopoietic activation | Inflammation | Heart Disease | Muscle | Smoking | Arterial inflammation | Tobacco | Female | Immunology | Prevention | Cardiovascular Conditions, Disorders and Treatments | Case-Control Studies | Fluorodeoxyglucose F18 | Autonomic Nervous System | Spleen | Tobacco and electronic cigarettes | Physiology | tobacco cigarettes | Electronic Nicotine Delivery Systems | Cardiovascular | Toxins, Pollutants and Chemical Agents | Heart | FDG‐PET/CT | Positron Emission Tomography Computed Tomography | Radiopharmaceuticals | Vascular disease | Signalling Pathways | Clinical Research | Aorta | Cancer | Original Research | Clinical Sciences | Adult | Positron emission tomography | Humans | Male

Abstract The “Splenocardiac Axis” describes an inflammatory signaling network underlying acute cardiac ischemia, characterized by sympathetic nerve stimulation of hematopoietic tissues, such as the bone marrow and spleen, which then release proinflammatory monocytes tha... View more