Barrett's Oesophagus in an Achalasia Patient: Immunological Analysis and Comparison with a Group of Achalasia Patients

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Torres-Landa, Samuel ; Furuzawa-Carballeda, Janette ; Coss-Adame, Enrique ; Valdovinos, Miguel A. ; Alejandro-Medrano, Edgar ; Ramos-Ávalos, Bárbara ; Martínez-Benítez, Braulio ; Torres-Villalobos, Gonzalo (2016)
  • Publisher: Hindawi Publishing Corporation
  • Journal: Case Reports in Gastrointestinal Medicine, volume 2,016 (issn: 2090-6528, eissn: 2090-6536)
  • Related identifiers: pmc: PMC5056281, doi: 10.1155/2016/5681590
  • Subject: Diseases of the digestive system. Gastroenterology | RC799-869 | Case Report | Article Subject
    mesheuropmc: digestive system | otorhinolaryngologic diseases | digestive system diseases

The aim of the study was to characterize the presence of diverse CD4 and CD8 T cell subsets and regulatory cells in peripheral blood and lower oesophageal sphincter (LES) from a young patient with BE/achalasia without treatment versus achalasia group. In order to characterize the circulating cells in this patient, a cytometric analysis was performed. LES tissue was evaluated by double-immunostaining procedure. Five healthy blood donors, 5 type achalasia patients, and 5 oesophagus tissue samples (gastrooesophageal junction) from transplant donors were included as control groups. A conspicuous systemic inflammation was determined in BE/achalasia patient and achalasia versus healthy volunteer group. Nonetheless, a predominance of Th22, Th2, IFN-α-producing T cells, Tregs, Bregs, and pDCregs was observed in BE/achalasia patient versus achalasia group. A low percentage of Th1 subset in BE/achalasia versus achalasia group was determined. A noticeable increase in tissue of Th22, Th17, Th2, Tregs, Bregs, and pDCregs was observed in BE/achalasia versus achalasia group. Th1 subset was lower in the BE/achalasia patient versus achalasia group. This study suggests that inflammation is a possible factor in the pathogenesis of BE/achalasia. Further research needs to be performed to understand the specific cause of the correlation between BE and achalasia.
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