Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

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de Saint-Jean, Maud; Delfosse, Vanessa; Douguet, Dominique; Chicanne, Gaetan; Payrastre, Bernard; Bourguet, William; Antonny, Bruno; Drin, Guillaume;
  • Journal: JOURNAL OF CELL BIOLOGY,volume 195,issue 6,pages965-978 (issn: 0021-9525, eissn: 1540-8140)
  • Related identifiers: doi: 10.1083/jcb.201104062, pmc: PMC3241724
  • Subject: MESH: Membrane Proteins | MESH: Saccharomyces cerevisiae Proteins | MESH: Phosphatidylinositol Phosphates | [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology | MESH: Liposomes | MESH: Receptors, Steroid | Research Articles | MESH: Lipid Bilayers | MESH: Ergosterol | Article | MESH: Protein Structure, Tertiary | [SDV.BC]Life Sciences [q-bio]/Cellular Biology

International audience; Osh/Orp proteins transport sterols between organelles and are involved in phosphoinositide metabolism. The link between these two aspects remains elusive. Using novel assays, we address the influence of membrane composition on the ability of Osh4... View more
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