The anti-repressor MecR2 promotes the proteolysis of the mecA repressor and enables optimal expression of β-lactam resistance in MRSA.

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Pedro Arêde ; Catarina Milheiriço ; Hermínia de Lencastre ; Duarte C Oliveira
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Pathogens, volume 8, issue 7, page e1002816 (issn: 1553-7366, eissn: 1553-7374)
  • Related identifiers: doi: 10.1371/journal.ppat.1002816, pmc: PMC3406092
  • Subject: Cellular Stress Responses | RC581-607 | Research Article | Molecular cell biology | Infectious diseases | Microbial Evolution | Methicillin-resistant Staphylococcus aureus | Staphylococcal infection | Immunologic diseases. Allergy | Bacteriology | Genetics | Bacterial Evolution | Molecular Genetics | Signaling in Cellular Processes | Biology | Signal Transduction | Microbiology | Mechanisms of Signal Transduction | Medicine | QH301-705.5 | Bacterial diseases | Medical Microbiology | DNA transcription | Gene Regulation | Transmembrane Signaling | Gene expression | Biology (General)
    mesheuropmc: bacterial infections and mycoses | biochemical phenomena, metabolism, and nutrition | polycyclic compounds

Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen, which is cross-resistant to virtually all β-lactam antibiotics. MRSA strains are defined by the presence of mecA gene. The transcription of mecA can be regulated by a sensor-inducer (MecR... View more
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