The Anti-Repressor MecR2 Promotes the Proteolysis of the mecA Repressor and Enables Optimal Expression of beta-lactam Resistance in MRSA

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Arêde, Pedro; Milheiriço, Catarina; de Lencastre, Hermínia; Oliveira, Duarte C.;
  • Journal: PLoS Pathogens,volume 8,issue 7,pagee1002816 (issn: 1553-7374, eissn: 1553-7374)
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  • Related identifiers: pmc: PMC3406092, doi: 10.1371/journal.ppat.1002816
  • Subject: Cellular Stress Responses | RC581-607 | Research Article | Molecular cell biology | Infectious diseases | Microbial Evolution | Methicillin-resistant Staphylococcus aureus | Staphylococcal infection | Immunologic diseases. Allergy | Bacteriology | Genetics | Bacterial Evolution | Molecular Genetics | Signaling in Cellular Processes | Biology | Signal Transduction | Microbiology | Mechanisms of Signal Transduction | Medicine | QH301-705.5 | Bacterial diseases | Medical Microbiology | DNA transcription | Gene Regulation | Transmembrane Signaling | Gene expression | Biology (General)
    mesheuropmc: bacterial infections and mycoses | biochemical phenomena, metabolism, and nutrition | polycyclic compounds

Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen, which is cross-resistant to virtually all β-lactam antibiotics. MRSA strains are defined by the presence of mecA gene. The transcription of mecA can be regulated by a sensor-inducer (MecR... View more
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