Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461.
James I Mullins
James P Hughes
Kim G Wong
Kevin S Harris
Jeffrey H Simpson
John M Essigmann
Lawrence A Loeb
- Publisher: Public Library of Science (PLoS)
(issn: 1932-6203, eissn: 1932-6203)
Antivirals | Research Article | Biology | Clinical Research Design | Infectious Diseases | Genetic Mutation | Microbiology | Medicine | Viral Diseases | Immunodeficiency Viruses | Viral Replication | Q | Microbial Mutation | R | Genetics | HIV | Virology | Science | Clinical Trials | Viral Nucleic Acid
The deoxycytidine analog KP1212, and its prodrug KP1461, are prototypes of a new class of antiretroviral drugs designed to increase viral mutation rates, with the goal of eventually causing the collapse of the viral population. Here we present an extensive analysis of v...