Rapid and precise measurement of serum branched-chain and aromatic amino acids by isotope dilution liquid chromatography tandem mass spectrometry.

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Ruiyue Yang ; Jun Dong ; Hanbang Guo ; Hongxia Li ; Shu Wang ; Haijian Zhao ; Weiyan Zhou ; Songlin Yu ; Mo Wang ; Wenxiang Chen
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 8, issue 12 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC3855216, doi: 10.1371/journal.pone.0081144
  • Subject: Q | R | Research Article | Science | Medicine

BACKGROUND: Serum branched-chain and aromatic amino acids (BCAAs and AAAs) have emerged as predictors for the future development of diabetes and may aid in diabetes risk assessment. However, the current methods for the analysis of such amino acids in biological samples ... View more
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