Cyclic GMP-AMP Displays Mucosal Adjuvant Activity in Mice

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Ivana Škrnjug; Carlos Alberto Guzmán; Christine Rueckert;
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 9, issue 10 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0110150, pmc: PMC4190368
  • Subject: Global Health | Research Article | Biology and Life Sciences | Infectious Disease Control | Infectious Diseases | Preventive Medicine | Medicine | Drug Research and Development | Vaccination and Immunization | Q | R | Public and Occupational Health | Science | Pharmacology | Medicine and Health Sciences | Immunology

The recently discovered mammalian enzyme cyclic GMP-AMP synthase produces cyclic GMP-AMP (cGAMP) after being activated by pathogen-derived cytosolic double stranded DNA. The product can stimulate STING-dependent interferon type I signaling. Here, we explore the efficacy... View more
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