publication . Article . Review . 2011

Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor

Nikolaos Vrachnis; Fotodotis M. Malamas; Stavros Sifakis; Panayiotis Tsikouras; Zoe Iliodromiti;
Open Access English
  • Published: 01 Oct 2011 Journal: Clinical and Developmental Immunology, volume 2,012 (issn: 1740-2522, eissn: 1740-2530, Copyright policy)
  • Publisher: Hindawi Publishing Corporation
Abstract
Progesterone and corticotropin-releasing hormone (CRH) have a critical role in pregnancy and labor, as changes related to these hormones are crucial for the transition from myometrial quiescence to contractility. The mechanisms related to their effect differ between humans and other species, thus, despite extensive research, many questions remain to be answered regarding their mediation in human labor. Immune responses to progesterone and CRH are important for labor. Progesterone acts as an immunomodulator which controls many immune actions during pregnancy, and its withdrawal releases the inhibitory action on inflammatory pathways. In humans, a “functional” pro...
Subjects
mesheuropmc: endocrine systemhormones, hormone substitutes, and hormone antagonists
free text keywords: RC581-607, Review Article, Immunologic diseases. Allergy, Article Subject
87 references, page 1 of 6

Mitchell, B. F., Taggart, M. J.. Are animal models relevant to key aspects of human parturition?. American Journal of Physiology. 2009; 297 (3): R525-R545

Smith, R.. Parturition. New England Journal of Medicine. 2007; 356 (3): 271-283

Osman, I., Young, A., Ledingham, M. A., Thomson, A. J., Jordan, F., Greer, I. A., Norman, J. E.. Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term. Molecular Human Reproduction. 2003; 9 (1): 41-45

Thomson, A. J., Telfer, J. F., Young, A., Campbell, S., Stewart, C. J. R., Cameron, I. T., Greer, I. A., Norman, J. E.. Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process. Human Reproduction. 1999; 14 (1): 229-236

Mittal, P., Romero, R., Tarca, A. L., Gonzalez, J., Draghici, S., Xu, Y., Dong, Z., Nhan-Chang, C. L., Chaiworapongsa, T., Lye, S., Kusanovic, J. P., Lipovich, L., Mazaki-Tovi, S., Hassan, S. S., Mesiano, S., Kim, C. J.. Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term. Journal of Perinatal Medicine. 2010; 38 (6): 617-643

Christiaens, I., Zaragoza, D. B., Guilbert, L., Robertson, S. A., Mitchell, B. F., Olson, D. M.. Inflammatory processes in preterm and term parturition. Journal of Reproductive Immunology. 2008; 79 (1): 50-57

Romero, R., Avila, C., Santhanam, U., Sehgal, P. B.. Amniotic fluid interleukin 6 in preterm labor. Association with infection. Journal of Clinical Investigation. 1990; 85 (5): 1392-1399 [OpenAIRE]

Romero, R., Gomez, R., Ghezzi, F., Bo Hyun Yoon, null, Mazor, M., Edwin, S. S., Berry, S. M.. A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition. American Journal of Obstetrics and Gynecology. 1998; 179 (1): 186-193

Witkin, S. S., Linhares, I. M., Bongiovanni, A. M., Herway, C., Skupski, D.. Unique alterations in infection-induced immune activation during pregnancy. International Journal of Obstetrics and Gynaecology. 2011; 118 (2): 145-153

Maldonado-Pérez, D., Golightly, E., Denison, F. C., Jabbour, H. N., Norman, J. E.. A role for lipoxin A4 as anti-inflammatory and proresolution mediator in human parturition. FASEB Journal. 2011; 25 (2): 569-575

Garfield, R. E., Sims, S., Daniel, E. E.. Gap junctions: their presence and necessity in myometrium during parturition. Science. 1977; 198 (4320): 958-960

Garfield, R. E., Hayashi, R. H.. Appearance of gap junctions in the myometrium of women during labor. American Journal of Obstetrics and Gynecology. 1981; 140 (3): 254-260

Zhao, K., Kuperman, L., Geimonen, E., Andersen, J.. Progestin represses human connexin43 gene expression similarly in primary cultures of myometrial and uterine leiomyoma cells. Biology of Reproduction. 1996; 54 (3): 607-615

Fuchs, A. R., Fuchs, F., Husslein, P., Soloff, M. S., Fernstrom, M. J.. Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor. Science. 1982; 215 (4538): 1396-1398

Fuchs, A. R., Fuchs, F., Husslein, P., Soloff, M. S.. Oxytocin receptors in the human uterus during pregnancy and parturition. American Journal of Obstetrics and Gynecology. 1984; 150 (6): 734-741

87 references, page 1 of 6
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publication . Article . Review . 2011

Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor

Nikolaos Vrachnis; Fotodotis M. Malamas; Stavros Sifakis; Panayiotis Tsikouras; Zoe Iliodromiti;