211 At-labeled agents for alpha-immunotherapy: On the in vivo stability of astatine-agent bonds

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Ayed, Tahra,; Pilmé, Julien; Tézé, David; Bassal, Fadel,; Barbet, Jacques,; Chérel, Michel; Champion, Julie,; Maurice, Rémi; Montavon, Gilles,; Galland, Nicolas,;
(2016)
  • Publisher: Elsevier
  • Related identifiers: doi: 10.1016/j.ejmech.2016.03.082
  • Subject: Bond enthalpy | In vivo stability | [SDV.CAN]Life Sciences [q-bio]/Cancer | Astatine | Targeted radionuclide therapy | Density functional theory | [ SDV.CAN ] Life Sciences [q-bio]/Cancer

International audience; The application of 211 At to targeted cancer therapy is currently hindered by the rapid deastatination that occurs in vivo. As the deastatination mechanism is unknown, we tackled this issue from the viewpoint of the intrinsic properties of At-inv... View more
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