A pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugs.

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McCarthy, James S.; Sekuloski, Silvana; Griffin, Paul M.; Elliott, Suzanne; Douglas, Nanette; Peatey, Chris; Rockett, Rebecca; O'Rourke, Peter; Marquart, Louise; Hermsen, Cornelius; Duparc, Stephan; Möhrle, Jörg; Trenholme, Katharine R.; Humberstone, Andrew J.;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 6,issue 8 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0021914, pmc: PMC3159571
  • Subject: Research Article | Biology | Tropical Diseases (Non-Neglected) | Adverse Reactions | Clinical research design | Infectious Diseases | Microbiology | Medicine | Malaria | Phase II | Q | R | Drug Discovery | Drugs and Devices | Plasmodium Falciparum | Biochemistry | Prospective Studies | Science | Parastic Protozoans | Protozoology | Clinical trials
    mesheuropmc: parasitic diseases

BACKGROUND: Critical to the development of new drugs for treatment of malaria is the capacity to safely evaluate their activity in human subjects. The approach that has been most commonly used is testing in subjects with natural malaria infection, a methodology that may... View more
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