publication . Article . 2013

The spatial pattern of light determines the kinetics and modulates backpropagation of optogenetic action potentials

Grossman, N; Simiaki, V; Martinet, C; Toumazou, C; Schultz, SR; Nikolic, K;
Open Access English
  • Published: 01 Jan 2013 Journal: JOURNAL OF COMPUTATIONAL NEUROSCIENCE, volume 34, issue 3, pages 477-488 (issn: 0929-5313, eissn: 1573-6873, Copyright policy)
  • Publisher: SPRINGER
Abstract
Optogenetics offers an unprecedented ability to spatially target neuronal stimulations. This study investigated via simulation, for the first time, how the spatial pattern of excitation affects the response of channelrhodopsin-2 (ChR2) expressing neurons. First we described a methodology for modeling ChR2 in the NEURON simulation platform. Then, we compared four most commonly considered illumination strategies (somatic, dendritic, axonal and whole cell) in a paradigmatic model of a cortical layer V pyramidal cell. We show that the spatial pattern of illumination has an important impact on the efficiency of stimulation and the kinetics of the spiking output. Whol...
Subjects
mesheuropmc: nervous system
free text keywords: Cellular and Molecular Neuroscience, Channelrhodopsin, Optogenetics, Neural stimulation, Sensory Systems, Cognitive Neuroscience, Article
Funded by
WT| Institutional Strategic Support Fund 2012/13
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 097816
  • Funding stream: Cross-Remit
,
EC| SEEBETTER
Project
SEEBETTER
Seeing Better with Hybrid BSI Spatio-Temporal Silicon Retina
  • Funder: European Commission (EC)
  • Project Code: 270324
  • Funding stream: FP7 | SP1 | ICT
Communities
FET FP7FET Proactive: FET proactive 8: Brain Inspired ICT
FET FP7FET Proactive: Seeing Better with Hybrid BSI Spatio-Temporal Silicon Retina
41 references, page 1 of 3

Andrasfalvy, B.K., Zemelman, B.V., Tang, J., Vaziri, A. (2010). Twophoton single-cell optogenetic control of neuronal activity by sculpted light. Proceedings of the National Academy of Sciences of the United States of America, 107(26), 11981-11986. [OpenAIRE]

Bamberg, E., Bamann, C., Feldbauer, K., Kleinlogel, S., Spitz, J., Zimmermann, D., Wood, P., Nagel, G. (2008). Channelrhodopsins: Molecular properties and applications In H. Keshishian (Ed.),, Optical Control of Neural Excitability, (pp.. 13-20). Washington, DC: Society for Neuroscience.

Boyden, E.S., Zhang, F., Bamberg, E., Nagel, G., Deisseroth, K. (2005). Millisecond-timescale, genetically targeted optical control of neural activity. Nature Neuroscience, 8(9), 1263-1268.

Busskamp, V., & Roska, B. (2011). Optogenetic approaches to restoring visual function in retinitis pigmentosa. Current Opinion in Neurobiology, 21, 1-5. [OpenAIRE]

Carnevale, N., & Hines, M. (2006). The neuron book. Cambridge, UK: Cambridge University Press.

Chow, B.Y., Han, X., Dobry, A.S., Qian, X., Chuong, A.S., Li, M., Henninger, M.A., Belfort, G.M., Lin, Y., Monahan, P.E., Boyden, E.S. (2010). High-performance genetically targetable optical neural silencing by light-driven proton pumps. Nature, 463(7277), 98-102. [OpenAIRE]

Degenaar, P., Grossman, N., Memon, M., Burrone, J., Dawson, M., Drakakis, E., Neil, M., Nikolic, K. (2009). Optobionic visiona new genetically enhanced light on retinal prosthesis. Journal of Neural Engineering, 6(3), 035007.

Feldbauer, K., Zimmermann, D., Pintschovius, V., Spitz, J., Bamann, C., Bamberg, E. (2009). Channelrhodopsin-2 is a leaky proton pump. Proceedings of the National Academy of Sciences of the United States of America, 106(30), 12317-12322. [OpenAIRE]

Grossman, N., Nikolic, K., Toumazou, C., Degenaar, P. (2011). Modeling study of the light stimulation of a neuron cell with channelrhodopsin-2 mutants. IEEE Transactions on Biomedical Engineering, 58(6), 1742-1751.

Grossman, N., Poher, P., Grubb, M.S., Kennedy, G.T., Nikolic, K., McGovern, B., Berlinguer Palmini, R., Gong, Z., Drakakis, E.M., Neil, M.A.A., Dawson, M.D., Burrone, J., Degenaar, P. (2010). Multi-site optical excitation using chr2 and micro-led array. Journal of Neural Engineering, 7(1), 016004.

Gunaydin, L.A., Yizhar, O., Berndt, A., Sohal, V.S., Deisseroth, K., Hegemann, P. (2010). Ultrafast optogenetic control. Nature Neuroscience, 13(3), 387-92.

Han, X., Qian, X., Bernstein, J.G., Zhou, H.H., Franzesi, G.T., Stern, P., Bronson, R.T., Graybiel, A.M., Desimone, R., Boyden, E.S. (2009). Millisecond-timescale optical control of neural dynamics in the nonhuman primate brain. Neuron, 62(2), 191-198.

Hay, E., Hill, S., Schrmann, F., Markram, H., Segev, I. (2011). Models of neocortical layer 5b pyramidal cells capturing awide range of dendritic and perisomatic active properties. PLoS Computational Biology, 7(7), e1002107.

Hegemann, P., Ehlenbeck, S., Gradmann, D. (2005). Multiple photocycles of channelrhodopsin. Biophysical Journal, 89(6), 3911-3918. [OpenAIRE]

Hines, M., & Carnevale, N. (1997). The neuron simulation environment. Neural Computation, 9, 1179-1209.

41 references, page 1 of 3
Abstract
Optogenetics offers an unprecedented ability to spatially target neuronal stimulations. This study investigated via simulation, for the first time, how the spatial pattern of excitation affects the response of channelrhodopsin-2 (ChR2) expressing neurons. First we described a methodology for modeling ChR2 in the NEURON simulation platform. Then, we compared four most commonly considered illumination strategies (somatic, dendritic, axonal and whole cell) in a paradigmatic model of a cortical layer V pyramidal cell. We show that the spatial pattern of illumination has an important impact on the efficiency of stimulation and the kinetics of the spiking output. Whol...
Subjects
mesheuropmc: nervous system
free text keywords: Cellular and Molecular Neuroscience, Channelrhodopsin, Optogenetics, Neural stimulation, Sensory Systems, Cognitive Neuroscience, Article
Funded by
WT| Institutional Strategic Support Fund 2012/13
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 097816
  • Funding stream: Cross-Remit
,
EC| SEEBETTER
Project
SEEBETTER
Seeing Better with Hybrid BSI Spatio-Temporal Silicon Retina
  • Funder: European Commission (EC)
  • Project Code: 270324
  • Funding stream: FP7 | SP1 | ICT
Communities
FET FP7FET Proactive: FET proactive 8: Brain Inspired ICT
FET FP7FET Proactive: Seeing Better with Hybrid BSI Spatio-Temporal Silicon Retina
41 references, page 1 of 3

Andrasfalvy, B.K., Zemelman, B.V., Tang, J., Vaziri, A. (2010). Twophoton single-cell optogenetic control of neuronal activity by sculpted light. Proceedings of the National Academy of Sciences of the United States of America, 107(26), 11981-11986. [OpenAIRE]

Bamberg, E., Bamann, C., Feldbauer, K., Kleinlogel, S., Spitz, J., Zimmermann, D., Wood, P., Nagel, G. (2008). Channelrhodopsins: Molecular properties and applications In H. Keshishian (Ed.),, Optical Control of Neural Excitability, (pp.. 13-20). Washington, DC: Society for Neuroscience.

Boyden, E.S., Zhang, F., Bamberg, E., Nagel, G., Deisseroth, K. (2005). Millisecond-timescale, genetically targeted optical control of neural activity. Nature Neuroscience, 8(9), 1263-1268.

Busskamp, V., & Roska, B. (2011). Optogenetic approaches to restoring visual function in retinitis pigmentosa. Current Opinion in Neurobiology, 21, 1-5. [OpenAIRE]

Carnevale, N., & Hines, M. (2006). The neuron book. Cambridge, UK: Cambridge University Press.

Chow, B.Y., Han, X., Dobry, A.S., Qian, X., Chuong, A.S., Li, M., Henninger, M.A., Belfort, G.M., Lin, Y., Monahan, P.E., Boyden, E.S. (2010). High-performance genetically targetable optical neural silencing by light-driven proton pumps. Nature, 463(7277), 98-102. [OpenAIRE]

Degenaar, P., Grossman, N., Memon, M., Burrone, J., Dawson, M., Drakakis, E., Neil, M., Nikolic, K. (2009). Optobionic visiona new genetically enhanced light on retinal prosthesis. Journal of Neural Engineering, 6(3), 035007.

Feldbauer, K., Zimmermann, D., Pintschovius, V., Spitz, J., Bamann, C., Bamberg, E. (2009). Channelrhodopsin-2 is a leaky proton pump. Proceedings of the National Academy of Sciences of the United States of America, 106(30), 12317-12322. [OpenAIRE]

Grossman, N., Nikolic, K., Toumazou, C., Degenaar, P. (2011). Modeling study of the light stimulation of a neuron cell with channelrhodopsin-2 mutants. IEEE Transactions on Biomedical Engineering, 58(6), 1742-1751.

Grossman, N., Poher, P., Grubb, M.S., Kennedy, G.T., Nikolic, K., McGovern, B., Berlinguer Palmini, R., Gong, Z., Drakakis, E.M., Neil, M.A.A., Dawson, M.D., Burrone, J., Degenaar, P. (2010). Multi-site optical excitation using chr2 and micro-led array. Journal of Neural Engineering, 7(1), 016004.

Gunaydin, L.A., Yizhar, O., Berndt, A., Sohal, V.S., Deisseroth, K., Hegemann, P. (2010). Ultrafast optogenetic control. Nature Neuroscience, 13(3), 387-92.

Han, X., Qian, X., Bernstein, J.G., Zhou, H.H., Franzesi, G.T., Stern, P., Bronson, R.T., Graybiel, A.M., Desimone, R., Boyden, E.S. (2009). Millisecond-timescale optical control of neural dynamics in the nonhuman primate brain. Neuron, 62(2), 191-198.

Hay, E., Hill, S., Schrmann, F., Markram, H., Segev, I. (2011). Models of neocortical layer 5b pyramidal cells capturing awide range of dendritic and perisomatic active properties. PLoS Computational Biology, 7(7), e1002107.

Hegemann, P., Ehlenbeck, S., Gradmann, D. (2005). Multiple photocycles of channelrhodopsin. Biophysical Journal, 89(6), 3911-3918. [OpenAIRE]

Hines, M., & Carnevale, N. (1997). The neuron simulation environment. Neural Computation, 9, 1179-1209.

41 references, page 1 of 3
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publication . Article . 2013

The spatial pattern of light determines the kinetics and modulates backpropagation of optogenetic action potentials

Grossman, N; Simiaki, V; Martinet, C; Toumazou, C; Schultz, SR; Nikolic, K;