The spatial pattern of light determines the kinetics and modulates backpropagation of optogenetic action potentials

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Grossman, Nir; Simiaki, Vasiliki; Martinet, Claire; Toumazou, Christofer; Schultz, Simon R.; Nikolic, Konstantin;
  • Publisher: Springer US
  • Journal: Journal of Computational Neuroscience,volume 34,issue 3,pages477-488 (issn: 0929-5313, eissn: 1573-6873)
  • Related identifiers: pmc: PMC3650242, doi: 10.1007/s10827-012-0431-7
  • Subject: Cellular and Molecular Neuroscience | Channelrhodopsin | Optogenetics | Neural stimulation | Sensory Systems | Cognitive Neuroscience | Article
    mesheuropmc: nervous system

Optogenetics offers an unprecedented ability to spatially target neuronal stimulations. This study investigated via simulation, for the first time, how the spatial pattern of excitation affects the response of channelrhodopsin-2 (ChR2) expressing neurons. First we descr... View more
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