Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells

Article, Other literature type English OPEN
Curti, Antonio ; Trabanelli, Sara ; Onofri, Chiara ; Aluigi, Michela ; Salvestrini, Valentina ; Ocadlikova, Darina ; Evangelisti, Cecilia ; Rutella, Sergio ; De Cristofaro, Raimondo ; Ottaviani, Emanuela ; Baccarani, Michele ; Lemoli, Roberto M. (2010)

Background: The immunoregulatory enzyme indoleamine 2,3-dioxygenase, which catalyzes the conversion of tryptophan into kynurenine, is expressed in a significant subset of patients with acute myeloid leukemia, resulting in the inhibition of T-cell proliferation and the i... View more
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