Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.

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Ng, Maggie C. Y.; Graff, Mariaelisa; Lu, Yingchang; Justice, Anne E.; Mudgal, Poorva; Liu, Ching-Ti; Young, Kristin; Yanek, Lisa R.; Feitosa, Mary F.; Wojczynski, Mary K.; Rand, Kristin; Brody, Jennifer A.; Cade, Brian E.; Dimitrov, Latchezar; Duan, Qing; Guo, Xiuqing; Lange, Leslie A.; Nalls, Michael A.; Okut, Hayrettin; Tajuddin, Salman M.; Tayo, Bamidele O.; Vedantam, Sailaja; Bradfield, Jonathan P.; Chen, Guanjie; Chen, Wei-Min; Chesi, Alessandra; Irvin, Marguerite R.; Padhukasahasram, Badri; Smith, Jennifer A.; Zheng, Wei; ... view all 112 authors
(2017)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Genetics, volume 13, issue 4 (issn: 1553-7390, eissn: 1553-7404)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pgen.1006719, doi: 10.1371/journal.pgen.1006719., pmc: PMC5419579
  • Subject: Computational Biology | Human Genetics | Research Article | Mathematics | Mathematical and Statistical Techniques | Genetic Loci | Population Groupings | QH426-470 | Genetics | Physical Sciences | People and Places | Genome Analysis | Genomics | Genomics Statistics | Alleles | Statistics (Mathematics) | Biology and Life Sciences | Signal Transduction | Research and Analysis Methods | Meta-Analysis | Ethnicities | Trait Locus Analysis | Africans | Cell Biology | Cell Signaling | Genomic Signal Processing | Genome-Wide Association Studies | Statistical Methods

Genome-wide association studies (GWAS) have identified >300 loci associated with measures of adiposity including body mass index (BMI) and waist-to-hip ratio (adjusted for BMI, WHRadjBMI), but few have been identified through screening of the African ancestry genomes. W... View more