SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes

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Tajima, Ken ; Yae, Toshifumi ; Javaid, Sarah ; Tam, Oliver ; Comaills, Valentine ; Morris, Robert ; Wittner, Ben S. ; Liu, Mingzhu ; Engstrom, Amanda ; Takahashi, Fumiyuki ; Black, Joshua C. ; Ramaswamy, Sridhar ; Shioda, Toshihiro ; Hammell, Molly ; Haber, Daniel A. ; Whetstine, Johnathan R. ; Maheswaran, Shyamala (2015)

Expression of the p53-inducible antiproliferative gene BTG2 is suppressed in many cancers in the absence of inactivating gene mutations, suggesting alternative mechanisms of silencing. Using a shRNA screen targeting 43 histone lysine methyltransferases (KMTs), we show t... View more
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