Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults

Article, Other literature type English OPEN
Smith, N. L. ; Huffman, J. E. ; Strachan, D. P. ; Huang, J. ; Dehghan, A. ; Trompet, S. ; Lopez, L. M. ; Shin, S.-Y. ; Baumert, J. ; Vitart, V. ; Bis, J. C. ; Wild, S. H. ; Rumley, A. ; Yang, Q. ; Uitterlinden, A. G. ; Stott, D. J. ; Davies, G. ; Carter, A. M. ; Thorand, B. ; Polasek, O. ; McKnight, B. ; Campbell, H. ; Rudnicka, A. R. ; Chen, M.-H. ; Buckley, B. M. ; Harris, S. E. ; Peters, A. ; Pulanic, D. ; Lumley, T. ; de Craen, A. J. M. ... view all 66 authors (2011)
  • Publisher: LIPPINCOTT WILLIAMS & WILKINS
  • Journal: Circulation, volume 123, issue 17, pages 1,864-1,872 (issn: 0009-7322, eissn: 1524-4539)
  • Related identifiers: doi: 10.1161/CIRCULATIONAHA.110.009480, pmc: PMC3095913
  • Subject: coronary | Cardiology and Cardiovascular Medicine | meta-analysis | polymorphism | hemostasis | von-willebrand-factor | Physiology (medical) | cardiovascular health | research | Article | epidemiology | heart-disease | myocardial-infarction | /dk/atira/pure/subjectarea/asjc/2700/2705 | /dk/atira/pure/subjectarea/asjc/2700/2737 | thrombosis | tissue-plasminogen activator | thr312ala | venous thromboembolism | genome-wide association study | risk | genome-wide association | aging | fibrin fragment D

Background-Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large... View more