Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults

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Smith, N. L.; Huffman, J. E.; Strachan, D. P.; Huang, J.; Dehghan, A.; Trompet, S.; Lopez, L. M.; Shin, S.-Y.; Baumert, J.; Vitart, V.; Bis, J. C.; Wild, S. H.; Rumley, A.; Yang, Q.; Uitterlinden, A. G.; Stott, D. J.; Davies, G.; Carter, A. M.; Thorand, B.; Polasek, O.; McKnight, B.; Campbell, H.; Rudnicka, A. R.; Chen, M.-H.; Buckley, B. M.; Harris, S. E.; Peters, A.; Pulanic, D.; Lumley, T.; de Craen, A. J. M.; ... view all 66 authors
  • Journal: CIRCULATION,volume 123,issue 17,pages1,864-1,872 (issn: 0009-7322, eissn: 1524-4539)
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  • Related identifiers: doi: 10.1161/CIRCULATIONAHA.110.009480
  • Subject: coronary | Cardiology and Cardiovascular Medicine | meta-analysis | polymorphism | hemostasis | von-willebrand-factor | Physiology (medical) | cardiovascular health | research | epidemiology | heart-disease | myocardial-infarction | /dk/atira/pure/subjectarea/asjc/2700/2705 | /dk/atira/pure/subjectarea/asjc/2700/2737 | thrombosis | tissue-plasminogen activator | thr312ala | venous thromboembolism | genome-wide association study | risk | genome-wide association | aging | fibrin fragment D

Background-Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large... View more