CK2 phosphorylation of Schistosoma mansoni HMGB1 protein regulates its cellular traffic and secretion but not its DNA transactions.

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de Abreu da Silva, Isabel Caetano; Carneiro, Vitor Coutinho; Maciel, Renata de Moraes; da Costa, Rodrigo Furtado Madeiro; Furtado, Daniel Rodrigues; de Oliveira, Francisco Meirelles Bastos; da Silva-Neto, Mário Alberto Cardoso; Rumjanek, Franklin David; Fantappié, Marcelo Rosado;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 6, issue 8 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Identifiers: doi: 10.1371/journal.pone.0023572, pmc: PMC3160966
  • Subject: Chromosome Structure and Function | Research Article | Biology | Molecular Cell Biology | Microbiology | Medicine | Nucleic Acids | Pathogenesis | Q | Parasite Physiology | R | Immunopathology | Proteins | Chromosome Biology | Biochemistry | Science | Immunology | Parasitology
    mesheuropmc: embryonic structures

BACKGROUND: The helminth Schistosoma mansoni parasite resides in mesenteric veins where fecundated female worms lay hundred of eggs daily. Some of the egg antigens are trapped in the liver and induce a vigorous granulomatous response. High Mobility Group Box 1 (HMGB1), ... View more
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