CK2 phosphorylation of Schistosoma mansoni HMGB1 protein regulates its cellular traffic and secretion but not its DNA transactions.

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Isabel Caetano de Abreu da Silva; Vitor Coutinho Carneiro; Renata de Moraes Maciel; Rodrigo Furtado Madeiro da Costa; Daniel Rodrigues Furtado; Francisco Meirelles Bastos de Oliveira; Mário Alberto Cardoso da Silva-Neto; Franklin David Rumjanek; Marcelo Rosado Fantappié;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 6,issue 8 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0023572, pmc: PMC3160966
  • Subject: Chromosome Structure and Function | Research Article | Biology | Molecular Cell Biology | Microbiology | Medicine | Nucleic Acids | Pathogenesis | Q | Parasite Physiology | R | Immunopathology | Proteins | Chromosome Biology | Biochemistry | Science | Immunology | Parasitology
    mesheuropmc: embryonic structures

BACKGROUND: The helminth Schistosoma mansoni parasite resides in mesenteric veins where fecundated female worms lay hundred of eggs daily. Some of the egg antigens are trapped in the liver and induce a vigorous granulomatous response. High Mobility Group Box 1 (HMGB1), ... View more
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