Identification of MAGE-3 Epitopes Presented by HLA-DR Molecules to CD4+ T Lymphocytes

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Chaux, P.; Vantomme, V.; Stroobant, V.; Thielemans, K.; Corthals, J.; Luiten, R.; Eggermont, A. M.; Boon, T.; van der Bruggen, P.;
  • Publisher: The Rockefeller University Press
  • Journal: The Journal of Experimental Medicine,volume 189,issue 5,pages767-778 (issn: 0022-1007, eissn: 1540-9538)
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  • Related identifiers: doi: 10.1084/jem.189.5.767, pmc: PMC2192951
  • Subject: peptide | Clone Cells | Antigen Presentation | Antigens, Neoplasm | Neoplasm Proteins | Melanoma | Peptides | Molecular Sequence Data | histocompatibility leukocyte antigen class II | Coculture Techniques | Epitopes | HLA-DR Antigens | Dendritic Cells | Amino Acid Sequence | invariant chain | tumor | CD4-Positive T-Lymphocytes | Humans | Articles | human | Male
    mesheuropmc: endocrine system | neoplasms

MAGE-type genes are expressed by many tumors of different histological types and not by normal cells, except for male germline cells, which do not express major histocompatibility complex (MHC) molecules. Therefore, the antigens encoded by MAGE-type genes are strictly t... View more