The Conserved nhaAR Operon Is Drastically Divergent between B2 and Non-B2 Escherichia coli and Is Involved in Extra-Intestinal Virulence

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Lescat, Mathilde; Reibel, Florence; Pintard, Coralie; Dion, Sara; Glodt, Jérémy; Gateau, Cecile; Launay, Adrien; Ledda, Alice; Cruvellier, Stephane; Tourret, Jérôme; Tenaillon, Olivier;
(2014)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 9, issue 9 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0108738, pmc: PMC4182557
  • Subject: Computational Biology | Mouse Models | Microbial Pathogens | Animal Models | Research Article | Transcription Factors | Infectious Diseases | Mice | [ SDV.MP.BAC ] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology | [ SDV.GEN.GPO ] Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] | Osmolar Concentration | Evolutionary Biology | Genetics | Hydrogen-Ion Concentration | Survival Rate | Phylogenetics | Genomics | Animals | Female | Evolutionary Systematics | Phenotype | DNA-Binding Proteins | Escherichia Coli | MD Multidisciplinary | Escherichia coli Proteins | Biology and Life Sciences | Research and Analysis Methods | Microbiology | Medicine | Bacterial Pathogens | Sodium-Hydrogen Antiporter | [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology | Operon | Comparative Genomics | Medical Microbiology | Q | Disease Models, Animal | R | [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] | Genome, Bacterial | Virulence | Model Organisms | Science | General Science & Technology | Phylogeny | Medicine and Health Sciences | Sepsis

International audience; The Escherichia coli species is divided in phylogenetic groups that differ in their virulence and commensal distribution. Strains belonging to the B2 group are involved in extra-intestinal pathologies but also appear to be more prevalent as comme... View more
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