Identification of estrogen receptor dimer selective ligands reveals growth-inhibitory effects on cells that co-express ERα and ERβ.

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Powell, Emily; Shanle, Erin; Brinkman, Ashley; Li, Jun; Keles, Sunduz; Wisinski, Kari B.; Huang, Wei; Xu, Wei;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 7,issue 2 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3274540, doi: 10.1371/journal.pone.0030993
  • Subject: Endocrine System | Computational Biology | Cellular Types | Research Article | Biology | Molecular Cell Biology | Signal Transduction | Medicine | Cancer Risk Factors | Membrane Receptor Signaling | Prostate Diseases | Anatomy and Physiology | Oncology | Q | R | Genitourinary Tract Tumors | Endocrine Physiology | Biochemistry | Obstetrics and Gynecology | Urology | Science | Cancers and Neoplasms | Endocrinology

Estrogens play essential roles in the progression of mammary and prostatic diseases. The transcriptional effects of estrogens are transduced by two estrogen receptors, ERα and ERβ, which elicit opposing roles in regulating proliferation: ERα is proliferative while ERβ i... View more