Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake

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Gardiner, JV; Bataveljic, A; Patel, NA; Bewick, GA; Roy, D; Campbell, D; Greenwood, HC; Murphy, KG; Hameed, S; Jethwa, PH; Ebling, FJP; Vickers, SP; Cheetham, S; Ghatei, MA; Bloom, SR; Dhillo, WS; (2009)
  • Publisher: American Diabetes Association
  • Journal: Diabetes,volume 59,issue 2,pages397-406 (issn: 0012-1797, eissn: 1939-327X)
  • Related identifiers: doi: 10.2337/db09-1198, pmc: PMC2809973
  • Subject: PROTEIN-COUPLED RECEPTORS | OBESE MICE | Neuropeptides | MICE LACKING | MELANOCYTE-STIMULATING HORMONE | Mice | Obesity Studies | Original Article | Endocrinology & Metabolism | Mice, Inbred C57BL | Rats, Wistar | MESSENGER-RNA | RNA, Messenger | Animals | Dose-Response Relationship, Drug | Rats | OLFACTORY-BULB | Obesity | Energy Intake | PITUITARY-ADRENAL AXIS | Injections, Intraventricular | Life Sciences & Biomedicine | CIRCADIAN-RHYTHMS | Motor Activity | Gene Expression Regulation | Science & Technology | Gastrointestinal Hormones | 11 Medical And Health Sciences | CART PEPTIDE | AMPHETAMINE-REGULATED TRANSCRIPT | Hypothalamus | Male
    mesheuropmc: hormones, hormone substitutes, and hormone antagonists | digestive, oral, and skin physiology

OBJECTIVE Prokineticin 2 (PK2) is a hypothalamic neuropeptide expressed in central nervous system areas known to be involved in food intake. We therefore hypothesized that PK2 plays a role in energy homeostasis. RESEARCH DESIGN AND METHODS We investigated the effect of ... View more
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