Split dosing of artemisinins does not improve antimalarial therapeutic efficacy

Article English OPEN
N. J. White; J. Watson; E. A. Ashley; (2017)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports,volume 7,issue 12,132 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: doi: 10.1038/s41598-017-12483-4, pmc: PMC5608907
  • Subject: Q | R | Science | Medicine | Article
    mesheuropmc: parasitic diseases

Abstract It has been suggested recently, based on pharmacokinetic-pharmacodynamic modelling exercises, that twice daily dosing of artemisinins increases malaria parasite killing and so could “dramatically enhance and restore drug effectiveness” in artemisinin resistant ... View more
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