Macrophages form functional vascular mimicry channels in vivo

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Barnett, Faith H. ; Rosenfeld, Mauricio ; Wood, Malcolm ; Kiosses, William B. ; Usui, Yoshihiko ; Marchetti, Valentina ; Aguilar, Edith ; Friedlander, Martin (2016)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports, volume 6 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: doi: 10.1038/srep36659, pmc: PMC5105153
  • Subject: Article

Macrophages, key cells of the innate immune system, are known to support angiogenesis but are not believed to directly form vessel walls. Here we show that macrophages structurally form primitive, NON-ENDOTHELIAL “vessels” or vascular mimicry (VM) channels in both tumor... View more
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