Characterization of plasma protein binding dissociation with online SPE-HPLC

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Li, Ping; Fan, Yiran; Wang, Yunlong; Lu, Yaxin; Yin, Zheng;
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports,volume 5 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: pmc: PMC4602217, doi: 10.1038/srep14866
  • Subject: Article
    mesheuropmc: viruses

A novel parameter of relative recovery (Rre) was defined and determined by online SPE-HPLC to characterize plasma protein binding (PPB) kinetics of highly plasma binding drugs. The proportional relationship of Rre with koff of PPB has been established with a new SPE mod... View more
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