Prospective cohort study using the breast cancer spheroid model as a predictor for response to neoadjuvant therapy - The SpheroNEO Study

Article, Doctoral thesis OPEN
Halfter, Kathrin; Ditsch, Nina; Kolberg, Hans-Christian; Fischer, Holger; Hauzenberger, Tanja; von Koch, Franz Edler; Bauerfeind, Ingo; von Minckwitz, Gunter; Funke, Ilona; Crispin, Alexander; Mayer, Barbara;
  • Publisher: Ludwig-Maximilians-Universität München
  • Journal: volume 15, issue 1issn: 1471-2407, eissn: 1471-2407
  • Publisher copyright policies & self-archiving
  • Identifiers: doi: 10.1186/s12885-015-1491-7, pmc: PMC4501185
  • Subject: Research Article | Breast cancer | Cellular response to anticancer drugs | in vitro diagnostics | Cancer Research | Oncology | Personalized medicine | Neoadjuvant chemotherapy | Genetics | Predicting treatment outcome | Medizinische Fakultät | Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie
    • ddc: ddc: | ddc:610 | ddc:600

Background Aim of this prospective study was to predict response to neoadjuvant therapy in breast cancer patients using an in vitro breast cancer spheroid model. Methods Three-dimensional spheroids were directly generated from fresh breast tumor biopsies of 78 patients ... View more
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