Microglial cell dysregulation in brain aging and neurodegeneration

Article English OPEN
von Bernhardi, Rommy ; Eugenín-von Bernhardi, Laura ; Eugenín, Jaime (2015)
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Aging Neuroscience, volume 7 (issn: 1663-4365, eissn: 1663-4365)
  • Related identifiers: pmc: PMC4507468, doi: 10.3389/fnagi.2015.00124, doi: 10.3389/fnagi.2015.00124/full
  • Subject: Neurosciences. Biological psychiatry. Neuropsychiatry | mitochondria | RC321-571 | Neuroscience | glia | Alzheimer’s disease | neurodegenerative diseases | neuroinflammation | transforming growth factor-β | Review | reactive oxygen species | Cytokines | Aging | oxidative stress

Aging is the main risk factor for neurodegenerative diseases. In aging, microglia undergoes phenotypic changes compatible with their activation. Glial activation can lead to neuroinflammation, which is increasingly accepted as part of the pathogenesis of neurodegenerati... View more
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