Tumorigenic properties of iron regulatory protein 2 (IRP2) mediated by its specific 73-amino acids insert.

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Maffettone, Carmen; Chen, Guohua; Drozdov, Ignat; Ouzounis, Christos; Pantopoulos, Kostas;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 5, issue 4 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Identifiers: pmc: PMC2854138, doi: 10.1371/journal.pone.0010163
  • Subject: Molecular Biology | Cell Biology/Cell Signaling | Research Article | Cell Biology/Cell Growth and Division | Medicine | Computational Biology/Comparative Sequence Analysis | Oncology | Cell Biology/Gene Expression | Q | R | Science | Hematology/Anemias | Molecular Biology/Translational Regulation | Molecular Biology/RNA-Protein Interactions

Iron regulatory proteins, IRP1 and IRP2, bind to mRNAs harboring iron responsive elements and control their expression. IRPs may also perform additional functions. Thus, IRP1 exhibited apparent tumor suppressor properties in a tumor xenograft model. Here we examined the... View more
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