A Silicon Nanomembrane Detector for Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) of Large Proteins

Article, Other literature type English OPEN
Park, Jonghoo; Blick, Robert H.;
(2013)

We describe a MALDI-TOF ion detector based on freestanding silicon nanomembrane technology. The detector is tested in a commercial MALDI-TOF mass spectrometer with equimolar mixtures of proteins. The operating principle of the nanomembrane detector is based on phonon-as... View more
  • References (18)
    18 references, page 1 of 2

    Instrum. 1955, 26, 1150-1157.

    Tanaka, K.; Waki, H.; Ido, Y.; Akita, S.; Yoshida, Y.; Yoshida, T.; Matsuo, T. Protein and polymer analyses up to m/z 100,000 by laser ionization time-of-flight mass spectrometry.

    Rapid Commun. Mass Spectrom. 1988, 2, 151-153.

    Karas, M.; Hillenkamp, F. Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. Anal. Chem. 1988, 60, 2299-2301.

    Geno, P.W. Mass Spectrometry in the Biological Sciences: A Tutorial, Ion Detection in MS; Kluwer Academic Publishers: Dordrecht, The Netherlands, 1992.

    Chen, X.; Westphall, M.S.; Smith, L.M. Mass spectrometric analysis of DNA mixtures: Instrumental effects responsible for decreased sensitivity with increasing mass. Anal. Chem. 2003, 75, 5944-5952.

    De Hoffmann, E.; Stroobant, V. Mass Spectrometry: Principles and Applications, 3rd ed.; John Wiley & Sons Inc.: Hoboken, NJ, USA, 2007.

    Park, J.; Qin, H.; Scalf, M.; Hilger, R.T.; Westphall, M.S.; Smith, L.M.; Blick, R.H. A mechanical nanomembrane detector for time-of-flight mass spectrometry. Nano Lett. 2011, 11, 3681-3684.

    Park, J.; Kim, H.; Blick, R.H. Quasi-dynamic mode of nanomembranes for time-of-flight mass spectrometry of proteins. Nanoscale 2012, 2, 2543-2548.

    Park, J.; Aksamija, Z.; Shin, H.-C.; Kim, H.; Blick, R.H. Phonon-assisted field emission in silicon nanomembranes for time-of-flight mass spectrometry of proteins. Nano Lett. 2013, 13, 2698-2703.

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