Association of genetic variants of the incretin-related genes with quantitative traits and occurrence of type 2 diabetes in Japanese

Article English OPEN
Enya, Mayumi; Horikawa, Yukio; Iizuka, Katsumi; Takeda, Jun;
(2014)
  • Publisher: Elsevier
  • Journal: Molecular Genetics and Metabolism Reports,volume 1,pages350-361 (issn: 2214-4269, eissn: 2214-4269)
  • Related identifiers: doi: 10.1016/j.ymgmr.2014.07.009, pmc: PMC5121356
  • Subject: OR, odds ratio | GIP, glucose-dependent insulinotropic peptide | PCSK1, prohormone convertase (PC) enzymes. PC1/3 | HOMA-R, homeostasis model assessment as an index of insulin resistance | Incretin | GCG, proglucagon gene | Polymorphism | GLP1R, GLP-1 receptor | HbA1c, hemoglobin A1c | PCR, polymerase chain reaction | SNP, single nucleotide polymorphism | LD, linkage disequilibrium | GIPR, GIP receptor | Type 2 diabetes | GLP-1, glucagon-like peptide 1 | BMI, body mass index | CPR, c-peptide immunoreactivity | Research Paper | GWAS, genome-wide association study | DPP4, dipeptidyl peptidase 4 | IRI, immunoreactive insulin | HOMA-B, homeostasis model assessment as an index of insulin secretion | Obesity | PCSK1

Background None of the high frequency variants of the incretin-related genes has been found by genome-wide association study (GWAS) for association with occurrence of type 2 diabetes in Japanese. However, low frequency and rare and/or high frequency variants affecting g... View more
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