CD98hc (SLC3A2) drives integrin-dependent renal cancer cell behavior

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Poettler, Marina; Unseld, Matthias; Braemswig, Kira; Haitel, Andrea; Zielinski, Christoph C; Prager, Gerald W;

Background Overexpression of CD98hc (SLC3A2) occurs in a variety of cancers and is suspected to contribute to tumor growth. CD98, a heterodimeric transmembrane protein, physically associates with certain integrin β subunit cytoplasmic domains via its heavy chain, CD98hc... View more
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