CD98hc (SLC3A2) drives integrin-dependent renal cancer cell behavior

Article English OPEN
Poettler, Marina; Unseld, Matthias; Braemswig, Kira; Haitel, Andrea; Zielinski, Christoph C; Prager, Gerald W; (2013)
  • Publisher: Springer Nature
  • Journal: Molecular Cancer,volume 12,pages169-169 (issn: 1476-4598, eissn: 1476-4598)
  • Related identifiers: pmc: PMC3879186, doi: 10.1186/1476-4598-12-169
  • Subject: Renal cell cancer | Molecular Medicine | Integrin | Research | CD98 | Cancer Research | Oncology

Background Overexpression of CD98hc (SLC3A2) occurs in a variety of cancers and is suspected to contribute to tumor growth. CD98, a heterodimeric transmembrane protein, physically associates with certain integrin β subunit cytoplasmic domains via its heavy chain, CD98hc... View more
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