CD98hc (SLC3A2) drives integrin-dependent renal cancer cell behavior

Article English OPEN
Poettler, Marina; Unseld, Matthias; Braemswig, Kira; Haitel, Andrea; Zielinski, Christoph C; Prager, Gerald W;
(2013)

Background Overexpression of CD98hc (SLC3A2) occurs in a variety of cancers and is suspected to contribute to tumor growth. CD98, a heterodimeric transmembrane protein, physically associates with certain integrin β subunit cytoplasmic domains via its heavy chain, CD98hc... View more
  • References (28)
    28 references, page 1 of 3

    1. Rini BI, et al: Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet 2011, 378(9807):1931-1939.

    2. Turnbull JD, Cobert J, Jaffe T, Harrison MR, George DJ, Armstrong AJ: Activity of single-agent bevacizumab in patients with metastatic renal cell carcinoma previously treated with vascular endothelial growth factor tyrosine kinase inhibitors. Clin Genitourin Cancer 2013, 11:45-50.

    3. Beuselinck B, Wolter P, Karadimou A, Elaidi R, Dumez H, Rogiers A, et al: Concomitant oral tyrosine kinase inhibitors and bisphosphonates in advanced renal cell carcinoma with bone metastases. Br J Cancer 2012, 107:1665-1671.

    4. Mulders PF: Renal cell carcinoma. World J Urol 2008, 26:113.

    5. Rini BI, Rathmell WK, Godley P: Renal cell carcinoma. Curr Opin Oncol 2008, 20:300-306.

    6. Prager GW, Poettler M, Schmidinger M, Mazal PR, Susani M, Zielinski CC, et al: CD98hc (SLC3A2), a novel marker in renal cell cancer. Eur J Clin Invest 2009, 39:304-310.

    7. Feral CC, Nishiya N, Fenczik CA, Stuhlmann H, Slepak M, Ginsberg MH: CD98hc (SLC3A2) mediates integrin signaling. Proc Natl Acad Sci USA 2005, 102(2):355-360.

    8. Tsumura H, Suzuki N, Saito H, Kawano M, Otake S, Kozuka Y, et al: The targeted disruption of the CD98 gene results in embryonic lethality. Biochem Biophys Res Commun 2003, 308:847-851.

    9. Henderson NC, Collis EA, Mackinnon AC, Simpson KJ, Haslett C, Zent R, et al: CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation. J Biol Chem 2004, 279:54731-54741.

    10. Rintoul RC, Buttery RC, Mackinnon AC, Wong WS, Mosher D, Haslett C, et al: Cross-linking CD98 promotes integrin-like signaling and anchorageindependent growth. Mol Biol Cell 2002, 13:2841-2852.

  • Similar Research Results (1)
  • Related Organizations (2)
  • Metrics
Share - Bookmark