The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas

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Lee, Yujin; Koh, Jaemoon; Kim, Seong-Ik; Won, Jae Kyung; Park, Chul-Kee; Choi, Seung Hong; Park, Sung-Hye;
  • Publisher: BioMed Central
  • Journal: Acta Neuropathologica Communications, volume 5 (issn: 2051-5960, eissn: 2051-5960)
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  • Related identifiers: pmc: PMC5574236, doi: 10.1186/s40478-017-0465-1
  • Subject: Alpha-thalassemia/mental retardation syndrome X-linked (ATRX) | Glioblastoma | Oligodendroglioma | Neurology. Diseases of the nervous system | Anaplastic astrocytoma | RC346-429 | Isocitrate dehydrogenase (IDH) | Telomerase reverse transcriptase | Research

Abstract Mutations in the telomerase reverse transcriptase gene promoter (TERTp) are common in glioblastomas (GBMs) and oligodendrogliomas (ODGs), and therefore, have a key role in tumorigenesis and may be of prognostic value. However, the extent of their prognostic imp... View more
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