Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal

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Ye, Shoudong; Zhang, Tao; Tong, Chang; Zhou, Xingliang; He, Kan; Ban, Qian; Liu, Dahai; Ying, Qi-Long;
(2017)
  • Publisher: The Company of Biologists Ltd
  • Journal: Biology Open,volume 6,issue 4,pages511-517 (issn: 2046-6390, eissn: 2046-6390)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5399551, doi: 10.1242/bio.022426
  • Subject: Differentiation | Research Article | Embryonic stem cells | TCF3 | Self-renewal | QH301-705.5 | Q | LEF1 | Science | Biology (General)
    mesheuropmc: biological phenomena, cell phenomena, and immunity | reproductive and urinary physiology | embryonic structures | urogenital system

ABSTRACT Mouse and rat embryonic stem cell (ESC) self-renewal can be maintained by dual inhibition of glycogen synthase kinase 3 (GSK3) and mitogen-activated protein kinase kinase (MEK). Inhibition of GSK3 promotes ESC self-renewal by abrogating T-cell factor 3 (TCF3)-m... View more
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