Skin Stem Cell Hypotheses and Long Term Clone Survival - Explored Using Agent-based Modelling

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Li, X. ; Upadhyay, A.K. ; Bullock, A.J. ; Dicolandrea, T. ; Xu, J. ; Binder, R.L. ; Robinson, M.K. ; Finlay, D.R. ; Mills, K.J. ; Bascom, C.C. ; Kelling, C.K. ; Isfort, R.J. ; Haycock, J.W. ; MacNeil, S. ; Smallwood, R.H. (2013)

Epithelial renewal in skin is achieved by the constant turnover and differentiation of keratinocytes. Three popular hypotheses have been proposed to explain basal keratinocyte regeneration and epidermal homeostasis: 1) asymmetric division (stem-transit amplifying cell);... View more
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