Atypical Processing of Gaze Cues and Faces Explains Comorbidity between Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD)

Article English OPEN
Groom, Madeleine J. ; Kochhar, Puja ; Hamilton, Antonia ; Liddle, Elizabeth B. ; Simeou, Marina ; Hollis, Chris (2017)
  • Publisher: Springer US
  • Journal: Journal of Autism and Developmental Disorders, volume 47, issue 5, pages 1,496-1,509 (issn: 0162-3257, eissn: 1573-3432)
  • Related identifiers: doi: 10.1007/s10803-017-3078-4, pmc: PMC5385202
  • Subject: ADHD | ASD | Comorbidity | Gaze cueing | Original Paper | Face processing | ASD, ADHD, ERPs, Comorbidity, Gaze cueing, Face processing, deficit hyperactivity disorder, infant neural sensitivity, dynamic eye gaze, individual-differences, reflexive attention, lateralized erps, social cues, arrow cues, plus adhd, children | ERPs
    mesheuropmc: genetic structures | behavioral disciplines and activities | mental disorders

This study investigated the neurobiological basis of comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). We compared children with ASD, ADHD or ADHD+ASD and typically developing controls (CTRL) on behavioural and electrophysiological correlates of gaze cue and face processing. We measured effects of ASD, ADHD and their interaction on the EDAN, an ERP marker of orienting visual attention towards a spatially cued location and the N170, a right-hemisphere lateralised ERP linked to face processing. We identified atypical gaze cue and face processing in children with ASD and ADHD+ASD compared with the ADHD and CTRL groups. The findings indicate a neurobiological basis for the presence of comorbid ASD symptoms in ADHD. Further research using larger samples is needed.
  • References (55)
    55 references, page 1 of 6

    Akiyama, T., Kato, M., Muramatsu, T., Saito, F., Umeda, S., & Kashima, H. (2006). Gaze but not arrows: A dissociative impairment after right superior temporal gyrus damage. Neuropsychologia, 44(10), 1804-1810. doi:10.1016/j. neuropsychologia.2006.03.007.

    American Psychiatric Association (A.P.A) (2013). Diagnostic and statistical manual of mental disorders (5th  edn.). Washington DC: American Psychiatric Association.

    Brignani, D., Guzzon, D., Marzi, C. A., & Miniussi, C. (2009). Attentional orienting induced by arrows and eye-gaze compared with an endogenous cue. Neuropsychologia, 47(2), 370-381. doi:10.1016/j.neuropsychologia.2008.09.011.

    Casagrande, M., Martella, D., Ruggiero, M. C., Maccari, L., Paloscia, C., Rosa, C., & Pasini, A. (2012). Assessing attentional systems in children with attention deficit hyperactivity disorder. Archives of Clinical Neuropsychology, 27(1), 30-44. doi:10.1093/arclin/ acr085.

    Chaumon, M., Bishop, D. V. M., & Busch, N. A. (2015). A practical guide to the selection of independent components of the electroencephalogram for artifact correction. Journal of Neuroscience Methods, 250, 47-63. doi:10.1016/j.jneumeth.2015.02.025.

    Conners, C. K. (1997). Conners' ratings scales: Revised technical manual. North Tanawanda: Multi-Health Systems Inc.

    Davies, M. S., Dapretto, M., Sigman, M., Sepeta, L., & Bookheimer, S. Y. (2011). Neural bases of gaze and emotion processing in children with autism spectrum disorders. Brain and Behavior, 1(1), 1-11. doi:10.1002/brb3.6.

    Davis, N. O., & Kollins, S. H. (2012). Treatment for co-occurring attention deficit/hyperactivity disorder and autism spectrum disorder. Neurotherapeutics, 9(3), 518-530. doi:10.1007/ s13311-012-0126-9.

    Delorme, A., & Makeig, S. (2004). EEGLAB: An open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Journal of Neuroscience Methods, 134(1), 9-21.

    Elsabbagh, M., Bruno, R., Wan, M. W., Charman, T., Johnson, M. H., & Green, J. (2015). Infant neural sensitivity to dynamic eye gaze relates to quality of parent-infant interaction at 7-months in infants at risk for autism. Journal of Autism and Developmental Disorders, 45(2), 283-291. doi:10.1007/s10803-014-2192-9.

  • Metrics
    0
    views in OpenAIRE
    0
    views in local repository
    41
    downloads in local repository

    The information is available from the following content providers:

    From Number Of Views Number Of Downloads
    Nottingham ePrints - IRUS-UK 0 31
    UCL Discovery - IRUS-UK 0 10
Share - Bookmark