Renal Bleeding Due to Extramedullary Hematopoiesis in a Patient With Chronic Myelogenous Leukemia*

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Zettner, Stephanie ; Mistry, Sandeep G. (2014)
  • Publisher: Elsevier
  • Journal: Urology Case Reports (issn: 2214-4420, vol: 2, pp: 183-185)
  • Related identifiers: pmc: PMC4782126, doi: 10.1016/j.eucr.2014.08.001
  • Subject: Hematuria | Renal infiltration | Extra-medullary hematopoiesis | Chronic myelogenous leukemia | Oncology
    mesheuropmc: hemic and lymphatic diseases | urologic and male genital diseases

Chronic myelogenous leukemia (CML) is a myeloproliferative disorder that normally presents in middle-aged adults. Renal infiltration and extramedullary hematopoiesis in renal tissue has been rarely reported. This case report presents a patient with CML and renal insufficiency who developed gross hematuria. Efforts at controlling the hematuria led to a cascade of events propelled by the underlying disorder that ultimately led to a radical nephrectomy, multiorgan failure, and prolonged hospitalization. We suggest that management of gross hematuria in clinically stable patients with CML, suspected of having extramedullary hematopoiesis, should prioritize treatment of the myeloproliferative disorder over efforts to control bleeding.
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