Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice

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Imai, Takafumi ; Takahashi, Yuki ; Nishikawa, Makiya ; Kato, Kana ; Morishita, Masaki ; Yamashita, Takuma ; Matsumoto, Akihiro ; Charoenviriyakul, Chonlada ; Takakura, Yoshinobu (2015)
  • Publisher: Co-Action Publishing
  • Journal: Journal of Extracellular Vesicles, volume 4 (issn: 2001-3078, eissn: 2001-3078)
  • Related identifiers: pmc: PMC4323410, doi: 10.3402/jev.v4.26238
  • Subject: Cytology | splenic macrophage | exosome; Kupffer cell; splenic macrophage; lactadherin; Gaussia luciferase; clearance | Original Research Article | lactadherin | clearance | QH573-671 | Gaussia luciferase | exosome | Kupffer cell

Previous studies using B16BL6-derived exosomes labelled with gLuc–lactadherin (gLuc-LA), a fusion protein of Gaussia luciferase (a reporter protein) and lactadherin (an exosome-tropic protein), showed that the exosomes quickly disappeared from the systemic circulation a... View more
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