Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice

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Imai, Takafumi; Takahashi, Yuki; Nishikawa, Makiya; Kato, Kana; Morishita, Masaki; Yamashita, Takuma; Matsumoto, Akihiro; Charoenviriyakul, Chonlada; Takakura, Yoshinobu;
(2015)
  • Publisher: Co-Action Publishing
  • Journal: Journal of Extracellular Vesicles,volume 4 (eissn: 2001-3078)
  • Related identifiers: pmc: PMC4323410, doi: 10.3402/jev.v4.26238
  • Subject: splenic macrophage | exosome; Kupffer cell; splenic macrophage; lactadherin; Gaussia luciferase; clearance | Original Research Article | lactadherin | clearance | Gaussia luciferase | exosome | Kupffer cell

Previous studies using B16BL6-derived exosomes labelled with gLuc–lactadherin (gLuc-LA), a fusion protein of Gaussia luciferase (a reporter protein) and lactadherin (an exosome-tropic protein), showed that the exosomes quickly disappeared from the systemic circulation a... View more
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