Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells.

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Madrigal, Andrés G.; Barth, Kenneth; Papadopoulos, George; Genco, Caroline Attardo;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Pathogens,volume 8,issue 6 (issn: 1553-7366, eissn: 1553-7374)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.ppat.1002723, pmc: PMC3369954
  • Subject: Host-Pathogen Interaction | Atherosclerosis | Oral Medicine | RC581-607 | Research Article | Biology | Immunity to Infections | Microbiology | Medicine | Immunity | Bacterial Pathogens | Gram Negative | Cardiovascular | Immunologic diseases. Allergy | QH301-705.5 | Medical Microbiology | Oral Diseases | Innate Immunity | Immune Defense | Immunology | Biology (General)

Porphyromonas gingivalis is the primary etiologic agent of periodontal disease that is associated with other human chronic inflammatory diseases, including atherosclerosis. The ability of P. gingivalis to invade and persist within human aortic endothelial cells (HAEC) h... View more