publication . Article . Other literature type . 2014

Pharmacological activation of NQO1 increases NAD+ levels and attenuates cisplatin-mediated acute kidney injury in mice

AiHua Shen; Jae-Hyuck Choi; Seong-Kyu Choe; Raekil Park; Seung Hoon Lee; Hong-Seob So; Chul-Ho Lee; Anzani Karna; Tae Hwan Kwak; Hyang Jeong Jo; ...
Open Access
  • Published: 01 Mar 2014 Journal: Kidney International, volume 85, issue 3, pages 547-560 (issn: 0085-2538, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Cisplatin is a widely used chemotherapeutic agent for the treatment of various tumors. In addition to its antitumor activity, cisplatin affects normal cells and may induce adverse effects, such as ototoxicity, nephrotoxicity, and neuropathy. Various mechanisms, such as DNA adduct formation, mitochondrial dysfunction, oxidative stress, and inflammatory responses, are critically involved in cisplatin-induced adverse effects. As NAD + is a cofactor for various enzymes associated with cellular homeostasis, we studied the effects of increased NAD + levels by means of NAD(P)H:quinone oxidoreductase 1 (NQO1) activation using a known pharmacological activator (β-lapacho...
Subjects
free text keywords: Nephrology, cisplatin, NAD+, nephrotoxicity, NQO1, sirtuins, Basic Research, Oxidative stress, medicine.disease_cause, medicine, NAD(P)H Dehydrogenase (Quinone), Cellular homeostasis, Biology, Sirtuin 1, biology.protein, Ototoxicity, medicine.disease, NAD+ kinase, Pharmacology, medicine.drug
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