Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line: impact on sorafenib cytotoxicity.

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Rigalli, Juan Pablo; Ciriaci, Nadia; Arias, Agostina; Ceballos, María Paula; Villanueva, Silvina Stella Maris; Luquita, Marcelo Gabriel; Mottino, Aldo Domingo; Ghanem, Carolina Inés; Catania, Viviana Alicia; Ruiz, Maria Laura;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 10,issue 3 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0119502, pmc: PMC4364073
  • Subject: Ciencias Biológicas | Research Article | Otras Ciencias Biológicas | SORAFENIB | HCC | MRP | Medicine | CIENCIAS NATURALES Y EXACTAS | Q | R | GENISTEIN | Bioquímica y Biología Molecular | HepG2 | Science | ABC transporters | MRPs inhibitor

Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide. Sorafenib is the only drug available that improves the overall survival of HCC patients. P-glycoprotein (P-gp), Multidrug resistance-associated proteins 2 and 3 (MRP2 and 3) and Breast cancer re... View more