Melatonin limits paclitaxel‐induced mitochondrial dysfunction in vitro and protects against paclitaxel‐induced neuropathic pain in the rat

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Galley, Helen F.; McCormick, Barry; Wilson, Kirsten L.; Lowes, Damon A.; Colvin, Lesley; Torsney, Carole;
(2017)
  • Publisher: John Wiley and Sons Inc.
  • Journal: Journal of Pineal Research, volume 63, issue 4 (issn: 0742-3098, eissn: 1600-079X)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5656911, doi: 10.1111/jpi.12444
  • Subject: Paclitaxel | C-FIBERS | antioxidant | mitochondria | SEX-DIFFERENCES | KAINATE MODEL | BREAST-CANCER | INDUCED PERIPHERAL NEUROPATHY | chemotherapy | NEURONAL DAMAGE | Original Article | neuropathic pain | TEMPORAL-LOBE EPILEPSY | Original Articles | ACETYL-L-CARNITINE | melatonin | CONDUCTION-VELOCITY | oxidative stress

<p>Chemotherapy-induced neuropathic pain is a debilitating and common side effect of cancer treatment. Mitochondrial dysfunction associated with oxidative stress in peripheral nerves has been implicated in the underlying mechanism. We investigated the potential of melat... View more
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