Isoform-specific interactions of the von Hippel-Lindau tumor suppressor protein

Article English OPEN
Minervini, Giovanni ; Mazzotta, Gabriella M. ; Masiero, Alessandro ; Sartori, Elena ; Corrà, Samantha ; Potenza, Emilio ; Costa, Rodolfo ; Tosatto, Silvio C. E. (2015)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports, volume 5 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: doi: 10.1038/srep12605, pmc: PMC4515828
  • Subject: Article
    mesheuropmc: urologic and male genital diseases | female genital diseases and pregnancy complications

Deregulation of the von Hippel-Lindau tumor suppressor protein (pVHL) is considered one of the main causes for malignant renal clear-cell carcinoma (ccRCC) insurgence. In human, pVHL exists in two isoforms, pVHL19 and pVHL30 respectively, displaying comparable tumor sup... View more
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