Genetic evidence for inhibition of bacterial division protein FtsZ by berberine.

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Boberek, Jaroslaw M.; Stach, Jem; Good, Liam;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 5,issue 10 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0013745, pmc: PMC2966414
  • Subject: Microbiology/Applied Microbiology | Biotechnology | Research Article | Microbiology | Biochemistry/Drug Discovery | Medicine | Q | R | Molecular Biology/mRNA Stability | Science | Molecular Biology/Translational Regulation | Infectious Diseases/Antimicrobials and Drug Resistance
    mesheuropmc: bacteria | macromolecular substances

BACKGROUND: Berberine is a plant alkaloid that is widely used as an anti-infective in traditional medicine. Escherichia coli exposed to berberine form filaments, suggesting an antibacterial mechanism that involves inhibition of cell division. Berberine is a DNA ligand a... View more
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