Synthesis, In Vitro and In Vivo Evaluation of the N-ethoxycarbonylmorpholine Ester of Diclofenac as a Prodrug

Other literature type, Article English OPEN
Jamal A. Jilani; Nasir M. Idkaidek; Karem H. Alzoubi;
(2014)
  • Publisher: Multidisciplinary Digital Publishing Institute
  • Journal: Pharmaceuticals,volume 7,issue 4,pages453-463 (issn: 1424-8247, eissn: 1424-8247)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.3390/ph7040453, pmc: PMC4014702
  • Subject: prodrug | ulcerogenicity | prodrug hydrolysis | pharmacokinetics | ethoxycarbonylmorpholine | diclofenac | Pharmacy and materia medica | Article | RS1-441
    mesheuropmc: stomatognathic diseases

The N-ethoxycarbonylmorpholine moiety was evaluated as a novel prodrug moiety for carboxylic acid containing drugs represented by diclofenac (1). Compound 2, the N-ethoxycarbonylmorpholine ester of diclofenac was synthesized and evaluated as a potential prodrug. The s... View more
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