The Minor Allele of rs7574865 in the STAT4 Gene Is Associated with Increased mRNA and Protein Expression
Ortiz, Ana María
- Publisher: Public Library of Science
(issn: 1932-6203, eissn: 1932-6203)
Q | R | Research Article | Science | Medicine
mesheuropmc: skin and connective tissue diseases | immune system diseases
Objective The T allele of rs7574865 in STAT4 confers risk of developing autoimmune disorders. However, its functional significance remains unclear. Here we analyze how rs7574865 affects the transcription of STAT4 and its protein expression. Methods We studied 201 patien...