The Minor Allele of rs7574865 in the STAT4 Gene Is Associated with Increased mRNA and Protein Expression

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Lamana, Amalia; López-Santalla, Mercedes; Castillo-González, Raquel; Ortiz, Ana María; Martín, Javier; García-Vicuña, Rosario; González-Álvaro, Isidoro;
  • Publisher: Public Library of Science
  • Journal: PLoS ONE,volume 10,issue 11 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC4646635, doi: 10.1371/journal.pone.0142683
  • Subject: Q | R | Research Article | Science | Medicine
    mesheuropmc: skin and connective tissue diseases | immune system diseases

Objective The T allele of rs7574865 in STAT4 confers risk of developing autoimmune disorders. However, its functional significance remains unclear. Here we analyze how rs7574865 affects the transcription of STAT4 and its protein expression. Methods We studied 201 patien... View more
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