publication . Article . 2005

Anti-lipid phosphate phosphohydrolase-3 (LPP3) antibody inhibits bFGF- and VEGF-induced capillary morphogenesis of endothelial cells

Humtsoe Joseph O; Wary Kishore K;
Open Access English
  • Published: 01 Aug 2005 Journal: Cell communication and signaling : CCS, volume 3, pages 9-9 (issn: 1478-811X, eissn: 1478-811X, Copyright policy)
  • Publisher: BioMed Central
Abstract
<p>Abstract</p> <p>Background</p> <p>Angiogenesis, or the remodeling of existing vasculature serves as a lifeline to nourish developing embryos and starved tissues, and to accelerate wound healing, diabetic retinopathy, and tumor progression. Recent studies indicate that angiogenesis requires growth factor activity as well as cell adhesion events mediated by α<sub>5</sub>β<sub>1 </sub>and α<sub>v</sub>β<sub>3 </sub>integrins. We previously demonstrated that human lipid phosphate phosphohydrolase-3 (LPP3) acts as a cell-associated ligand for α<sub>5</sub>β<sub>1 </sub>and α<sub>v</sub>β<sub>3 </sub>integrins. Here, we test the hypothesis that an anti-LPP3 antibod...
Subjects
free text keywords: collagen matrices, Cytology, endothelial cells, R, VCIP, capillary morphogenesis, VEGF, Medicine, QH573-671, bFGF, Research
42 references, page 1 of 3

Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1995; 1: 27-31 [PubMed] [DOI]

Hanahan, D, Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 1996; 86: 353-364 [OpenAIRE] [PubMed] [DOI]

Ferrara, N, Davis-Smyth, T. The biology of vascular endothelial growth factor. Endocr Rev. 1997; 8: 4-25 [PubMed] [DOI]

Carmeliet, P, Jain, RK. Angiogenesis in cancer and other diseases. Nature. 2000; 407: 249-257 [PubMed] [DOI]

Sato, Y, Kanno, S, Oda, N, Abe, M, Ito, M, Shitara, K, Shibuya, M. Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction. Ann N Y Acad Sci. 2000; 902: 201-205 [OpenAIRE] [PubMed]

Ferrara, N. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol. 2001; 280: C1358-1366 [PubMed]

Werb, Z. ECM and cell surface proteolysis: regulating cellular ecology. Cell. 1997; 91: 439-442 [OpenAIRE] [PubMed] [DOI]

Shapiro, SD. Matrix metalloproteinase degradation of extracellular matrix: biological consequences. Curr Opin Cell Biol. 1998; 10: 602-608 [PubMed] [DOI]

Wary, KK. Molecular targets for anti-angiogenic therapy. Curr Opin Mol Ther. 2004; 6: 54-70 [PubMed]

Varner, JA, Cheresh, DA. Tumor angiogenesis and the role of vascular cell integrin alphavbeta3. Important Adv Oncol. 1996: 69-87 [PubMed]

Varner, JA. The role of vascular cell integrins alpha v beta 3 and alpha v beta 5 in angiogenesis. EXS. 1997; 79: 361-390 [PubMed]

Eliceiri, BP, Cheresh, DA. The role of alpha v integrins during angiogenesis. Mol Med. 1998; 4: 741-750 [OpenAIRE] [PubMed]

Ruoslahti, E, Engvall, E. Integrins and vascular extracellular matrix assembly. J Clin Invest. 1997; 100: S53-56 [OpenAIRE] [PubMed]

Elicieri, BP, Cheresh, DA, Emile E Voest, Patricia A Damore, null. Alphav beta3 integrin and its antagonists in the control of angiogenesis. Tumor angiogenesis and Microcirculation. 2001: 387-398

Hynes, RO. Integrins: bidirectional, allosteric signaling machines. Cell. 2000; 110: 673-687 [PubMed] [DOI]

42 references, page 1 of 3
Abstract
<p>Abstract</p> <p>Background</p> <p>Angiogenesis, or the remodeling of existing vasculature serves as a lifeline to nourish developing embryos and starved tissues, and to accelerate wound healing, diabetic retinopathy, and tumor progression. Recent studies indicate that angiogenesis requires growth factor activity as well as cell adhesion events mediated by α<sub>5</sub>β<sub>1 </sub>and α<sub>v</sub>β<sub>3 </sub>integrins. We previously demonstrated that human lipid phosphate phosphohydrolase-3 (LPP3) acts as a cell-associated ligand for α<sub>5</sub>β<sub>1 </sub>and α<sub>v</sub>β<sub>3 </sub>integrins. Here, we test the hypothesis that an anti-LPP3 antibod...
Subjects
free text keywords: collagen matrices, Cytology, endothelial cells, R, VCIP, capillary morphogenesis, VEGF, Medicine, QH573-671, bFGF, Research
42 references, page 1 of 3

Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1995; 1: 27-31 [PubMed] [DOI]

Hanahan, D, Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 1996; 86: 353-364 [OpenAIRE] [PubMed] [DOI]

Ferrara, N, Davis-Smyth, T. The biology of vascular endothelial growth factor. Endocr Rev. 1997; 8: 4-25 [PubMed] [DOI]

Carmeliet, P, Jain, RK. Angiogenesis in cancer and other diseases. Nature. 2000; 407: 249-257 [PubMed] [DOI]

Sato, Y, Kanno, S, Oda, N, Abe, M, Ito, M, Shitara, K, Shibuya, M. Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction. Ann N Y Acad Sci. 2000; 902: 201-205 [OpenAIRE] [PubMed]

Ferrara, N. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J Physiol Cell Physiol. 2001; 280: C1358-1366 [PubMed]

Werb, Z. ECM and cell surface proteolysis: regulating cellular ecology. Cell. 1997; 91: 439-442 [OpenAIRE] [PubMed] [DOI]

Shapiro, SD. Matrix metalloproteinase degradation of extracellular matrix: biological consequences. Curr Opin Cell Biol. 1998; 10: 602-608 [PubMed] [DOI]

Wary, KK. Molecular targets for anti-angiogenic therapy. Curr Opin Mol Ther. 2004; 6: 54-70 [PubMed]

Varner, JA, Cheresh, DA. Tumor angiogenesis and the role of vascular cell integrin alphavbeta3. Important Adv Oncol. 1996: 69-87 [PubMed]

Varner, JA. The role of vascular cell integrins alpha v beta 3 and alpha v beta 5 in angiogenesis. EXS. 1997; 79: 361-390 [PubMed]

Eliceiri, BP, Cheresh, DA. The role of alpha v integrins during angiogenesis. Mol Med. 1998; 4: 741-750 [OpenAIRE] [PubMed]

Ruoslahti, E, Engvall, E. Integrins and vascular extracellular matrix assembly. J Clin Invest. 1997; 100: S53-56 [OpenAIRE] [PubMed]

Elicieri, BP, Cheresh, DA, Emile E Voest, Patricia A Damore, null. Alphav beta3 integrin and its antagonists in the control of angiogenesis. Tumor angiogenesis and Microcirculation. 2001: 387-398

Hynes, RO. Integrins: bidirectional, allosteric signaling machines. Cell. 2000; 110: 673-687 [PubMed] [DOI]

42 references, page 1 of 3
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publication . Article . 2005

Anti-lipid phosphate phosphohydrolase-3 (LPP3) antibody inhibits bFGF- and VEGF-induced capillary morphogenesis of endothelial cells

Humtsoe Joseph O; Wary Kishore K;