An Objective Approach for Burkholderia pseudomallei Strain Selection as Challenge Material for Medical Countermeasures Efficacy Testing

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Van Zandt, Kristopher E.; Tuanyok, Apichai; Keim, Paul S.; Warren, Richard L.; Gelhaus, H. Carl;
  • Publisher: Frontiers Research Foundation
  • Journal: Frontiers in Cellular and Infection Microbiology,volume 2 (issn: 2235-2988, eissn: 2235-2988)
  • Related identifiers: pmc: PMC3458228, doi: 10.3389/fcimb.2012.00120
  • Subject: genome | Review Article | animal models | virulence | Microbiology | passage history | pseudomallei | biodefense | aerosol | sequencing

Burkholderia pseudomallei is the causative agent of melioidosis, a rare disease of biodefense concern with high mortality and extreme difficulty in treatment. No human vaccines are available that protect against B. pseudomallei infection, and with the current limitation... View more
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