publication . Article . Other literature type . 2014

Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays for transdermal delivery of high dose, low molecular weight drugs

Ryan F. Donnelly; Ahlam Zaid Alkilani; Ahlam Zaid Alkilani; Emma McAlister; Helen O. McCarthy; Maelíosa T.C. McCrudden; A. David Woolfson; Cian M. McCrudden;
Open Access
  • Published: 01 Apr 2014 Journal: Journal of Controlled Release, volume 180, pages 71-80 (issn: 0168-3659, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United Kingdom
Abstract
Graphical abstract
doi: 10.1016/j.jconrel.2014.02.007
pmid: 24556420
pmc: PMC4034161
Subjects
free text keywords: Pharmaceutical Science, Microneedles, Administration, Cutaneous, Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Drug Delivery Systems, Equipment Design, Humans, Male, Microinjections, Molecular Weight, Needles, Pharmaceutical Preparations, Polymers, Rats, Rats, Sprague-Dawley, Skin, Skin Absorption, Solubility, Swine, Article, Chemistry, Ibuprofen, medicine.drug, medicine, Transdermal, In vivo, Pharmacology, Chromatography, Biocompatibility, Iontophoresis, Drug, media_common.quotation_subject, media_common, Maleic acid, chemistry.chemical_compound, Absorption (skin)
Related Organizations
View more
Funded by
RCUK| Transdermal delivery of macromolecules mediated by microneedle arrays
Project
Transdermal delivery of macromolecules mediated by microneedle arrays
  • Funder: Research Council UK (RCUK)
  • Project Code: BB/E020534/1
  • Funding stream: BBSRC
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34 references, page 1 of 3

Ito, Y., Hirono, M., Fukushima, K., Sugioka, N., Takada, K.. Two-layered dissolving microneedles formulated with intermediate-acting insulin. Int. J. Pharm.. 2012; 436: 387-393 [PubMed]

Liu, S., Jin, M.N., Quan, Y.S., Kamiyama, F., Katsumi, H., Sakane, T., Yamamoto, A.. The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin. J. Control. Release. 2012; 161: 933-941 [PubMed]

Donnelly, R.F., Morrow, D.I.J., Singh, T.R.R., Migalska, K., McCarron, P.A., O'Mahony, C., Woolfson, A.D.. Processing difficulties and instability of carbohydrate microneedle arrays. Drug Dev. Ind. Pharm.. 2009; 35: 1242-1254 [OpenAIRE] [PubMed]

Lee, J.W., Park, J.H., Prausnitz, M.R.. Dissolving microneedles for transdermal drug delivery. Biomaterials. 2008; 29: 2113-2124 [OpenAIRE] [PubMed]

Gomaa, Y.A., Garland, M.J., McInnes, F., El-Khordagui, L.K., Wilson, C., Donnelly, R.F.. Laser-engineered dissolving microneedles for active transdermal delivery of nadroparin calcium. Eur. J. Pharm. Biopharm.. 2012; 82: 299-307 [OpenAIRE] [PubMed]

Matsuo, K., Yokota, Y., Zhai, Y., Quan, Y.S., Kamiyama, F., Mukai, Y., Okada, N., Nakagawa, S.. A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens. J. Control. Release. 2012; 161: 10-17 [PubMed]

Naito, S., Ito, Y., Kiyohara, T., Kataoka, M., Ochiai, M., Takada, K.. Antigen-loaded dissolving microneedle array as a novel tool for percutaneous vaccination. Vaccine. 2012; 30: 1191-1197 [OpenAIRE] [PubMed]

Sullivan, S.P., Koutsonanos, D.G., Del Pilar Martin, M., Lee, J.W., Zarnitsyn, V., Choi, S.O., Murth, N., Compans, R.W., Skountzou, I., Prausnitz, M.R.. Dissolving polymer microneedle patches for influenza vaccination. Nat. Med.. 2010; 16: 915-920 [OpenAIRE] [PubMed]

Matsuo, K., Hirobe, S., Yokota, Y., Ayabe, Y., Seto, M., Quan, Y.S., Kamiyama, F., Tougan, T., Horii, T., Mukai, Y., Okada, N., Nakagawa, S.. Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza. J. Control. Release. 2012; 160: 495-501 [PubMed]

Garland, M.J., Caffarel-Salvador, E., Migalska, K., Woolfson, A.D., Donnelly, R.F.. Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery. J. Control. Release. 2012; 159 (2012): 52-59 [OpenAIRE] [PubMed]

Migalska, K., Morrow, D.I., Garland, M.J., Thakur, R., Woolfson, A.D., Donnelly, R.F.. Laser-engineered dissolving microneedle arrays for transdermal macromolecular drug delivery. Pharm. Res.. 2011; 28: 1919-1930 [PubMed]

McCrudden, M.T., Singh, T.R., Migalska, K., Donnelly, R.F.. Strategies for enhanced peptide and protein delivery. Ther. Deliv.. 2013; 4: 593-614 [PubMed]

Tuan-Mahmood, T.M., McCrudden, M.T.C., Torrisi, B.M., McAlister, E., Garland, M.J., Singh, T.R., Donnelly, R.F.. Microneedles for intradermal and transdermal drug delivery. Eur. J. Pharm. Sci.. 2013 [OpenAIRE]

Benson, H.A.E., Watkinson, A.C.. 2012

Donnelly, R.F., Majithiya, R., Singh, T.R., Morrow, D.I., Garland, M.J., Demir, Y.K., Migalska, K., Ryan, E., Gillen, D., Scott, C.J., Woolfson, A.D.. Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique. Pharm. Res.. 2011; 28: 41-57 [OpenAIRE] [PubMed]

34 references, page 1 of 3
Related research
Abstract
Graphical abstract
doi: 10.1016/j.jconrel.2014.02.007
pmid: 24556420
pmc: PMC4034161
Subjects
free text keywords: Pharmaceutical Science, Microneedles, Administration, Cutaneous, Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Drug Delivery Systems, Equipment Design, Humans, Male, Microinjections, Molecular Weight, Needles, Pharmaceutical Preparations, Polymers, Rats, Rats, Sprague-Dawley, Skin, Skin Absorption, Solubility, Swine, Article, Chemistry, Ibuprofen, medicine.drug, medicine, Transdermal, In vivo, Pharmacology, Chromatography, Biocompatibility, Iontophoresis, Drug, media_common.quotation_subject, media_common, Maleic acid, chemistry.chemical_compound, Absorption (skin)
Related Organizations
View more
Funded by
RCUK| Transdermal delivery of macromolecules mediated by microneedle arrays
Project
Transdermal delivery of macromolecules mediated by microneedle arrays
  • Funder: Research Council UK (RCUK)
  • Project Code: BB/E020534/1
  • Funding stream: BBSRC
Download fromView all 7 versions
Journal of Controlled Release
Article
Provider: UnpayWall
Elsevier
Article
Provider: CORE (RIOXX-UK Aggregator)
Queen's University Research Portal
Article . 2014
Provider: Queen's University Research Portal
BASE (Open Access Aggregator)
Article . 2014
Provider: BASE (Open Access Aggregator)
View more
34 references, page 1 of 3

Ito, Y., Hirono, M., Fukushima, K., Sugioka, N., Takada, K.. Two-layered dissolving microneedles formulated with intermediate-acting insulin. Int. J. Pharm.. 2012; 436: 387-393 [PubMed]

Liu, S., Jin, M.N., Quan, Y.S., Kamiyama, F., Katsumi, H., Sakane, T., Yamamoto, A.. The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin. J. Control. Release. 2012; 161: 933-941 [PubMed]

Donnelly, R.F., Morrow, D.I.J., Singh, T.R.R., Migalska, K., McCarron, P.A., O'Mahony, C., Woolfson, A.D.. Processing difficulties and instability of carbohydrate microneedle arrays. Drug Dev. Ind. Pharm.. 2009; 35: 1242-1254 [OpenAIRE] [PubMed]

Lee, J.W., Park, J.H., Prausnitz, M.R.. Dissolving microneedles for transdermal drug delivery. Biomaterials. 2008; 29: 2113-2124 [OpenAIRE] [PubMed]

Gomaa, Y.A., Garland, M.J., McInnes, F., El-Khordagui, L.K., Wilson, C., Donnelly, R.F.. Laser-engineered dissolving microneedles for active transdermal delivery of nadroparin calcium. Eur. J. Pharm. Biopharm.. 2012; 82: 299-307 [OpenAIRE] [PubMed]

Matsuo, K., Yokota, Y., Zhai, Y., Quan, Y.S., Kamiyama, F., Mukai, Y., Okada, N., Nakagawa, S.. A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens. J. Control. Release. 2012; 161: 10-17 [PubMed]

Naito, S., Ito, Y., Kiyohara, T., Kataoka, M., Ochiai, M., Takada, K.. Antigen-loaded dissolving microneedle array as a novel tool for percutaneous vaccination. Vaccine. 2012; 30: 1191-1197 [OpenAIRE] [PubMed]

Sullivan, S.P., Koutsonanos, D.G., Del Pilar Martin, M., Lee, J.W., Zarnitsyn, V., Choi, S.O., Murth, N., Compans, R.W., Skountzou, I., Prausnitz, M.R.. Dissolving polymer microneedle patches for influenza vaccination. Nat. Med.. 2010; 16: 915-920 [OpenAIRE] [PubMed]

Matsuo, K., Hirobe, S., Yokota, Y., Ayabe, Y., Seto, M., Quan, Y.S., Kamiyama, F., Tougan, T., Horii, T., Mukai, Y., Okada, N., Nakagawa, S.. Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza. J. Control. Release. 2012; 160: 495-501 [PubMed]

Garland, M.J., Caffarel-Salvador, E., Migalska, K., Woolfson, A.D., Donnelly, R.F.. Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery. J. Control. Release. 2012; 159 (2012): 52-59 [OpenAIRE] [PubMed]

Migalska, K., Morrow, D.I., Garland, M.J., Thakur, R., Woolfson, A.D., Donnelly, R.F.. Laser-engineered dissolving microneedle arrays for transdermal macromolecular drug delivery. Pharm. Res.. 2011; 28: 1919-1930 [PubMed]

McCrudden, M.T., Singh, T.R., Migalska, K., Donnelly, R.F.. Strategies for enhanced peptide and protein delivery. Ther. Deliv.. 2013; 4: 593-614 [PubMed]

Tuan-Mahmood, T.M., McCrudden, M.T.C., Torrisi, B.M., McAlister, E., Garland, M.J., Singh, T.R., Donnelly, R.F.. Microneedles for intradermal and transdermal drug delivery. Eur. J. Pharm. Sci.. 2013 [OpenAIRE]

Benson, H.A.E., Watkinson, A.C.. 2012

Donnelly, R.F., Majithiya, R., Singh, T.R., Morrow, D.I., Garland, M.J., Demir, Y.K., Migalska, K., Ryan, E., Gillen, D., Scott, C.J., Woolfson, A.D.. Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique. Pharm. Res.. 2011; 28: 41-57 [OpenAIRE] [PubMed]

34 references, page 1 of 3
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