Transduction of skin-migrating dendritic cells by human adenovirus 5 occurs via an actin-dependent phagocytic pathway

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Guzman, Efrain ; Taylor, Geraldine ; Hope, Jayne ; Herbert, Rebecca ; Cubillos-Zapata, Carolina ; Charleston, Bryan (2016)
  • Publisher: Microbiology Society
  • Journal: The Journal of General Virology, volume 97, issue 10, pages 2,703-2,718 (issn: 0022-1317, eissn: 1465-2099)
  • Related identifiers: pmc: PMC5078831, doi: 10.1099/jgv.0.000581
  • Subject: Standard | dendritic cells | Large DNA Viruses | Animal | adenovirus entry | afferent lymph dendritic cells | receptor-independent endocytosis
    mesheuropmc: viruses

Dendritic cells (DC) are central to the initiation of immune responses, and various approaches have been used to target vaccines to DC in order to improve immunogenicity. Cannulation of lymphatic vessels allows for the collection of DC that migrate from the skin. These ... View more