Neutralisation of Interleukin-13 in Mice Prevents Airway Pathology Caused by Chronic Exposure to House Dust Mite

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Tomlinson, Kate L. ; Davies, Gareth C. G. ; Sutton, Daniel J. ; Palframan, Roger T. (2010)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 5, issue 10 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0013136, pmc: PMC2948524
  • Subject: Q | Immunology/Immunomodulation | R | Research Article | Science | Respiratory Medicine/Asthma | Medicine | Immunology/Allergy and Hypersensitivity
    mesheuropmc: respiratory system | respiratory tract diseases

BACKGROUND: Repeated exposure to inhaled allergen can cause airway inflammation, remodeling and dysfunction that manifests as the symptoms of allergic asthma. We have investigated the role of the cytokine interleukin-13 (IL-13) in the generation and persistence of airwa... View more
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