Sequence specific suppression of androgen receptor–DNA binding in vivo by a Py-Im polyamide

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Kurmis, Alexis A; Dervan, Peter B;

Abstract The crucial role of androgen receptor (AR) in prostate cancer development is well documented, and its inhibition is a mainstay of prostate cancer treatment. Here, we analyze the perturbations to the AR cistrome caused by a minor groove binding molecule that is ... View more
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