Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator

Article English OPEN
Filipp, Fabian V. (2013)
  • Publisher: Medknow Publications & Media Pvt Ltd
  • Journal: Journal of Carcinogenesis, volume 12 (issn: 0974-6773, eissn: 1477-3163)
  • Related identifiers: pmc: PMC3746496, doi: 10.4103/1477-3163.115423
  • Subject: pyruvate dehydrogenase | systems biology | serine | Review Article | catenin | pyruvate dehydrogenase kinase | pyruvate kinase M2 | 6-bisphosphatase | succinylaminoimidazolecarboxamide ribose-5-phosphate | Neoplasms. Tumors. Oncology. Including cancer and carcinogens | feedback | NMR | PKM2 | metabolomics | pyruvate kinase | 6-bisphosphate | epidermal growth factor receptor | control | signal transducer and activator of transcription 3 | PKM1 | seven in absentia homolog 2 | Cancer metabolism | Warburg | omics | MYC | RC254-282 | fructose-1 | glutaminase | serine/arginine-rich splicing factor 3 | feed-forward | glutamic-oxalacetic transaminase | hypoxia-inducible factor 1-alpha | isoform

Pyruvate kinase activity is controlled by a tightly woven regulatory network. The oncofetal isoform of pyruvate kinase (PKM2) is a master regulator of cancer metabolism. PKM2 engages in parallel, feed-forward, positive and negative feedback control contributing to cance... View more
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